Versiunea Romana

Development Of The Conceptual Model Of A Lab-On-A-Chip For Continuous Particles Separation Through Magnetophoresis And Dielectrophoresis


During this project we are investigating, using multidisciplinary fundamental research activities, the most advanced innovative aspects of: (1) interactions within supra-molecular biological systems; (2) observation of new interactions; (3) solving the mechanisms which trigger the behavior of biophysical systems; (4) thorough investigation of the hemodynamic structures and processes at the molecular and cellular level; (5) development of new concepts regarding the electrophoresis, dielectrophoresis and magnetophoresis phenomena; (6) applications of these phenomena for theoretical formulation and development of a lab-on-a-chip. For sorting, manipulating and counting biocells. The need to approach such a thematic is justified by the benefits of developing such a microfluidic device: reduced size, ability to separate biological cells according to size and properties, ability to perform preliminary analysis, all this making it priceless for blood analysis laboratories for sorting, manipulating and analyzing the bioparticles.

Main objectives:
    (1) molecular dynamic studies of the electrophoretic, dielectrophoretic and magnetophoretic regimes of biomolecules.
    (2) thermo-electro-magnetic modeling and complex structural analysis studies.
    (3) formulation of self-consistent theories for describing the interaction of nano-biosystems with the electromagnetic field.
    (4) numerical simulations with specialized software adapted for the optimisation of the results.
    (5) development of an advanced lab-on-a-chip concept for dielectrophoretic and magnetophoretic separation of biocells.