A “system-in-a-microfluidic package” approach for focused diagnostic DNA microchips

(MicroChip pentru diagnosticare bazat pe ADN integrat intr-un sistem microfluidic)

MNT-ERA project, MNT 7-015 /2008

Project Coordinator:  Universite Catholique de Louvain



The main objectives of this project were:
- designing and technological fabrication of an sensor and an microfluidic device, but also, designing and fabrication  of an microarray system by modifying surfaces and immobilisation of some DNA probes on its;
- development of the sensors system based on complementary detection by combining differrent ideas: with/without fluorecence labbeling;
- microfluidic platform fabrication for real time monitoring;

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For experimental realization of a test structure for detection of DNA used a surface nanostructured porous silicon, which offers the advantage of integration in a microfluidic system made form Belgium partners. Using a p-type silicon wafer (100) with 5-10Ωcm resistivity a porous structure was obtained by the electrochemical etching of silicon in 13% hydrofluoric acid solution and a current of 20mA/cm2.;

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Project Coordinator:  Universite catholique de Louvain

- University of Liege
- Coris BioConcept
- IMT-Bucharest
- Genetic Lab SRL

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- Monica Simion, Lorand Savu, Antonio Radoi, Mihaela Miu, Adina Bragaru, ”Surface nano structuration role in detection of HPV using microarray technology”,  Journal of  Nanoscience and Nanotechnology,  2011

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